HLA表現與變異

HLA 基因呈遞(Present)路徑

CD8+ T-Cell Expression

CD4+ T-Cell Expression

HLA 結構變異(Structural Variation;SV)

Conventional docking

Alternate docking

TCR stabilization of weak peptide_HLA complexes

Altered register

Hotspot binding and molecular mimicry

PTM-altered HLA binding

PTM-altered antigen processing

HLA presentation of hybrid peptides

Stability and peptide repertoire

**圖文來源 NATURE REVIEWS Published online 2 Jan 2018 : 

Calliope A. Dendrou, Jan Petersen, Jamie Rossjohn and Lars Fugger. HLA variation and disease.  NATURE REVIEWS | IMMUNOLOGY: 1-15 (2018)